Hemoglobin Alpha 1 + 2 (HBA1,HBA2) (AA 10-60) antibody

Catalog No. ABIN1387969

This Rabbit Polyclonal antibody specifically detects in IHC (p) and IF (p). It exhibits reactivity toward Human and Mouse.

Quick Overview for Hemoglobin Alpha 1 + 2 (HBA1,HBA2) (AA 10-60) antibody (ABIN1387969)

Target: Hemoglobin Alpha 1 + 2 (HBA1,HBA2)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details

Binding Specificity: AA 10-60

Cross-Reactivity: Human, Mouse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Hemoglobin alpha

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details

Target: Hemoglobin Alpha 1 + 2 (HBA1,HBA2)

Alternative Name: HBA1+HBA2

Background:

Synonyms: HBH, HBA-T3, Hemoglobin subunit alpha, Alpha-globin, Hemoglobin alpha chain, HBA1

Background: The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97 % of the total hemoglobin, alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3 % of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1, some nondeletion alpha thalassemias have also been reported. [provided by RefSeq, Jul 2008].

Gene ID: 3039

UniProt: P69905