RECQL5 antibody (AA 1-100) (AbBy Fluor® 647)

Catalog No. ABIN1390050

This anti-RECQL5 antibody is a Rabbit Polyclonal antibody detecting RECQL5 in IF (cc) and IF (p). Suitable for Human.

Quick Overview for RECQL5 antibody (AA 1-100) (AbBy Fluor® 647) (ABIN1390050)

Target: RECQL5 (RecQ Protein-Like 5 (RECQL5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RECQL5 antibody is conjugated to AbBy Fluor® 647

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-RECQL5 Antibody (AbBy Fluor® 647)

Binding Specificity: AA 1-100

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RECQL5

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for RECQL5

Target: RECQL5 (RecQ Protein-Like 5 (RECQL5))

Alternative Name: RECQL5

Background:

Synonyms: ATP-dependent DNA helicase Q5, DNA helicase, RecQ like type 5, DNA helicase, RECQ-like, type 5, RecQ helicase protein-like 5 beta, RecQ protein-like 5, RecQ protein-like 5, isoform CRA_b, RecQ5, Recq5b, Recql5b.

Background: RecQ helicases are implicated in DNA recombination and repair helicases and are critical in genome maintenance. RecQL5 is one of five known RecQ homologues in humans, and defects in three of these (BLM, WRN and RecQ4)are associated with autosomal recessive disorders that involve genomic instability and a predisposition to cancer. The exact role of ReqL5 is unclear. It has been shown in mouse embryonic stem (ES) cells that mutations in the Recql5 genes result in a significant increase in the frequency of sister chromatid exchange (SCE), whereas deleting Recql5 lead to an even higher frequency of SCE. There are three different RecQL5 isoforms - alpha, beta and gamma, produced by alternative splicing.