NOVA1 antibody (AA 411-510) (Biotin)

Catalog No. ABIN1390597

This Rabbit Polyclonal antibody specifically detects NOVA1 in WB, ELISA, IHC (p) and IHC (fro). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for NOVA1 antibody (AA 411-510) (Biotin) (ABIN1390597)

Target: NOVA1 (Neuro-Oncological Ventral Antigen 1 (NOVA1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NOVA1 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-NOVA1 Antibody (Biotin)

Binding Specificity: AA 411-510

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Cow,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NOVA1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for NOVA1

Target: NOVA1 (Neuro-Oncological Ventral Antigen 1 (NOVA1))

Alternative Name: Nova1

Background:

Synonyms: Neuro oncological ventral antigen 1, Neuro-oncological ventral antigen 1, NOVA 1, Nova-1, Nova1, NOVA1_HUMAN, Onconeural ventral antigen 1, Paraneoplastic Ri antigen, RNA binding protein Nova 1, RNA-binding protein Nova-1, Ventral neuron specic protein 1, Ventral neuron-specic protein 1.

Background: Nova-1 and Nova-2 are members of a superfamily of protein regulators of RNA metabolism in neurons. Both are nuclear RNA binding proteins with K homology motifs, conserved protein sequences which bind to RNA (1,2). Nova proteins, normally sequestered in the central nervous system, are expressed by systemic tumors in patients with the autoimmune disorder paraneoplastic opsoclonus-myoclonus ataxia (POMA) (3,4). Nova-1 is expressed in the hindbrain and ventral spinal cord and Nova-2 is expressed in the neocortex and hippocampus (4). Nova-1 is necessary for regulating neuron-specific alternative splicing of the glycine receptor Alpha2 pre-mRNA (5).

UniProt: P51513