Calsyntenin 2 antibody (AA 261-360) (AbBy Fluor® 488)

Catalog No. ABIN1390684

This Rabbit Polyclonal antibody specifically detects Calsyntenin 2 in IF (cc) and IF (p). It exhibits reactivity toward Mouse.

Quick Overview for Calsyntenin 2 antibody (AA 261-360) (AbBy Fluor® 488) (ABIN1390684)

Target: Calsyntenin 2 (CLSTN2)

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Calsyntenin 2 antibody is conjugated to AbBy Fluor® 488

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-Calsyntenin 2 Antibody (AbBy Fluor® 488)

Binding Specificity: AA 261-360

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CLSTN2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Calsyntenin 2

Target: Calsyntenin 2 (CLSTN2)

Alternative Name: CLSTN2

Background:

Synonyms: Alc, Alcadein, Alcadein Gamma, Alcagamma, Alzheimer's disease related cadherin like protein, Calsyntenin 2, CLSTN 2, CS 2, CS2, FLJ39113, FLJ39499, MGC119560, CSTN2_HUMAN.

Background: Members of the calsyntenin protein family are localized to the post-synaptic membrane of exicitatory central nervous system (CNS) synapses. Calsyntenin-2, also known as Alcadein-gamma, is a 955 amino acid protein that localizes to the endoplasmic reticulum, golgi apparatus and plasma membranes. Containing 2 cadherin-like repeats in its N-terminal extracellular region, calsyntenin-2 binds synaptic calcium with its cytoplasmic domain, suggesting a role in the modulation of calcium-mediated postsynaptic signals. Under normal physiological conditions, calsyntenin-2 is protoeolytically processed in an event in which the primary zeta-cleavage generates a short C-terminal transmembrane fragment and a long extracellular N-terminal domain.