ICA1 antibody (AA 1-100) (Biotin)

Catalog No. ABIN1390747

This Rabbit Polyclonal antibody specifically detects ICA1 in WB, ELISA, IHC (p), IHC (fro). It exhibits reactivity toward Human.

Quick Overview for ICA1 antibody (AA 1-100) (Biotin) (ABIN1390747)

Target: ICA1 (Islet Cell Autoantigen 1, 69kDa (ICA1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ICA1 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-ICA1 Antibody (Biotin)

Binding Specificity: AA 1-100

Predicted Reactivity: Human,Mouse,Rat,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ICA1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for ICA1

Target: ICA1 (Islet Cell Autoantigen 1, 69kDa (ICA1))

Alternative Name: ICA1

Background:

Synonyms: 69 kDa islet cell autoantigen, Diabetes mellitus type I autoantigen, ICA 1, ICA1, ICA69, ICA69_HUMAN, ICAp69, Islet cell autoantigen 1 69kD, Islet cell autoantigen 1 69 kDa, Islet cell autoantigen 1, Islet cell autoantigen 1 isoform, Islet cell autoantigen p69, OTTHUMP00000200933, OTTHUMP00000200934, OTTHUMP00000200941, OTTHUMP00000200993, p69.

Background: Carbonic anhydrases (CAs), also designated carbonate dehydratases or carbonate hydrolyases, form a large family of genes that encode zinc metalloenzymes of great physiologic importance. As catalysts of the reversible hydration of carbon dioxide, these enzymes participate in a variety of biologic processes, including respiration, acid-base balance, bone resorption and calcification as well as the formation of aqueous humor, cerebrospinal fluid, saliva and gastric acid. Genes in the ?carbonic anhydrase family encode either active carbonic anhydrase isozymes or _catalytic?(devoid of CO2 hydration activity) carbonic anhydrase-related proteins. Human CA I (CA1) is encoded by the CA1 gene, which maps to a region on chromosome 8 that harbors a cluster of CA genes. CA I localizes to the cytoplasm and research indicates that a severe deficiency of CA I does not result in any obvious hematological or renal consequences.