ATRNL1 antibody (AA 501-600) (Biotin)

Catalog No. ABIN1391659

This Rabbit Polyclonal antibody specifically detects ATRNL1 in ELISA, IHC (fro) and IHC (p). It exhibits reactivity toward Human.

Quick Overview for ATRNL1 antibody (AA 501-600) (Biotin) (ABIN1391659)

Target: ATRNL1 (Attractin-Like 1 (ATRNL1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATRNL1 antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-ATRNL1 Antibody (Biotin)

Binding Specificity: AA 501-600

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ATRNL1

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for ATRNL1

Target: ATRNL1 (Attractin-Like 1 (ATRNL1))

Alternative Name: ATRNL1

Background:

Synonyms: ATRN1_HUMAN, ATRNL1, Attractin-like protein 1, KIAA0534.

Background: ATRNL1 is a 1,379 amino acid single-pass type I membrane protein that may play a role in melanocortin signaling pathways that regulate energy homeostasis. The ATRNL1 protein contains a C-type lectin domain, a CUB domain, two EGF-like domains, six Kelch repeats, two laminin EGF-like domains and five PSI domains. ATRNL1 interacts with MC4-R in several regions known to be important in the regulation of energy homeostasis by melanocortins, such as the paraventricular nucleus of hypothalamus and the dorsal motor nucleus of the vagus. The ATRNL1 gene is conserved in dog, cow, mouse, rat, chicken, zebrafish and C. elegans, exists as two alternatively spliced isoforms and maps to human chromosome 10q25.3. Strong evidence of linkage to late-onset Alzheimer disease (LOAD) is linked to chromosome 10, which implicates a wide region and at least one disease-susceptibility locus.