NR6A1 antibody (AA 251-350) (AbBy Fluor® 350)

Catalog No. ABIN1391979

Product Details anti-NR6A1 Antibody (AbBy Fluor® 350)

Target: NR6A1 (Nuclear Receptor Subfamily 6, Group A, Member 1 (NR6A1))

Binding Specificity: AA 251-350

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NR6A1 antibody is conjugated to AbBy Fluor® 350

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GCNF

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for NR6A1

Target: NR6A1 (Nuclear Receptor Subfamily 6, Group A, Member 1 (NR6A1))

Alternative Name: GCNF (NR6A1 Products)

Background:

Synonyms: GCNF 1, GCNF, GCNF1, Germ cell nuclear factor, hGCNF, hRTR, NR 61, NR61, NR6A1, NR6A1_HUMAN, Nuclear receptor subfamily 6 group A member 1, Orphan nuclear receptor NR6A1, Retinoic acid receptor related testis associated receptor, Retinoid receptor related testis specic receptor, Retinoid receptor-related testis-specic receptor, RTR.

Background: Germ cell nuclear factor (GCNF) is an orphan member of the nuclear receptor gene superfamily that influences neurogenesis and germ cell development. GCNF can homodimerize and bind DNA. GCNF regulates paracrine interaction between the oocyte and somatic cells by regulating the expression of BMP-15 and GDF-9, to affect female fertility. GCNF is present in spermatocytes and round spermatids of adult male mouse testis, northern blot and ribonuclease protection assays have shown GCNF is predominant in the testis. The gene expresses three alternatively spliced transcript variants.

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway