LMCD1 antibody (AA 51-160) (Biotin)

Catalog No. ABIN1393837

This Rabbit Polyclonal antibody specifically detects LMCD1 in WB, ELISA, IHC (p) and IHC (fro). It exhibits reactivity toward Human.

Quick Overview for LMCD1 antibody (AA 51-160) (Biotin) (ABIN1393837)

Target: LMCD1 (LIM and Cysteine-Rich Domains 1 (LMCD1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LMCD1 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-LMCD1 Antibody (Biotin)

Binding Specificity: AA 51-160

Predicted Reactivity: Human,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human LMCD1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for LMCD1

Target: LMCD1 (LIM and Cysteine-Rich Domains 1 (LMCD1))

Alternative Name: LMCD1

Background:

Synonyms: Dyxin, LIM and cysteine rich domains 1, LIM and cysteine rich domains protein 1, LIM and cysteine-rich domains protein 1, LMCD1_HUMAN.

Background: Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T cells signaling pathway.