NELL2 antibody (AA 201-300) (AbBy Fluor® 555)

Catalog No. ABIN1393961

The Rabbit Polyclonal anti-NELL2 antibody has been validated for WB, IF (cc), IF (p). It is suitable to detect NELL2 in samples from Mouse, Rat.

Quick Overview for NELL2 antibody (AA 201-300) (AbBy Fluor® 555) (ABIN1393961)

Target: NELL2 (NEL-Like 2 (Chicken) (NELL2))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NELL2 antibody is conjugated to AbBy Fluor® 555

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-NELL2 Antibody (AbBy Fluor® 555)

Binding Specificity: AA 201-300

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NELL2/NRP2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for NELL2

Target: NELL2 (NEL-Like 2 (Chicken) (NELL2))

Alternative Name: NELL2/NRP2

Background:

Synonyms: A330108N19Rik, Mel91, MEL91 protein, NEL like 2 chicken, NEL-like protein 2, Nel-related protein 2, NELL2, NELL2_HUMAN, NRP2, Protein kinase C-binding protein NELL2, R75516.

Background: NELL2 is a secreted glycoprotein with one N-terminal TSP-like domain, five VWFC (von Willebrand factor C) domains and six EGF-like repeats that participate in calcium binding. NELL2 exists as a homotrimer associated with the endoplasmic reticulum (ER) and is specifically expressed in neurons playing a role in calcium-dependent intracellular events. NELL2 may act as a trophic factor in addition to its role as a signaling molecule implicated in the regulation of cell growth and differentiation. Due to alternative splicing, an additional NELL2 isoform exists that is identical to full length NELL2 except that it lacks the signal peptide that directs secretion. The additional isoform is therefore retained in the cytosol and functions as a non-secreted cytoplasmic protein that interacts with PKC bI.