NPDC1 antibody (AA 75-180) (FITC)

Catalog No. ABIN1394066

The Rabbit Polyclonal anti-NPDC1 antibody has been validated for WB, IF (cc) and IF (p). It is suitable to detect NPDC1 in samples from Mouse.

Quick Overview for NPDC1 antibody (AA 75-180) (FITC) (ABIN1394066)

Target: NPDC1 (Neural Proliferation, Differentiation and Control, 1 (NPDC1))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NPDC1 antibody is conjugated to FITC

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-NPDC1 Antibody (FITC)

Binding Specificity: AA 75-180

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NPDC1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for NPDC1

Target: NPDC1 (Neural Proliferation, Differentiation and Control, 1 (NPDC1))

Alternative Name: NPDC1

Background:

Synonyms: AI314472, CAB1, Neural proliferation dferentiation and control protein 1, NPDC-1, NPDC1, NPDC1_HUMAN.

Background: NPDC-1 (Neural Proliferation Differentiation and Control-1) is expressed in neurons once they have stopped dividing and begun to differentiate. NPDC-1 is transported from the Golgi apparatus via vesicles before becoming internalized by endosomes at the cell membrane. NPDC-1 interacts with Cdk2, D-type cyclins, and the transcription factor E2F1. This interaction can lead to an increased replication time, and might have implications in final neural differentiation and apoptosis. NPDC-1 has been shown to colocalize with synaptic vesicle proteins: synaptophysin, synaptobrevin 2, and Rab3 GEP (Rab3 GTP/GDP exchange protein). One function of NPDC-1 is to regulate retinoic acid-mediated events by directly interacting with retinoid receptors. The amino acid sequence of NPDC-1 is highly conserved between mouse, rat, and human.