NCS1 antibody (AA 1-50) (Biotin)

Catalog No. ABIN1394437

This Rabbit Polyclonal antibody specifically detects NCS1 in WB, ELISA, IHC (p) and IHC (fro). It exhibits reactivity toward Rat.

Quick Overview for NCS1 antibody (AA 1-50) (Biotin) (ABIN1394437)

Target: NCS1 (Neuronal Calcium Sensor 1 (NCS1))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NCS1 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-NCS1 Antibody (Biotin)

Binding Specificity: AA 1-50

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Cow

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NCS1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for NCS1

Target: NCS1 (Neuronal Calcium Sensor 1 (NCS1))

Alternative Name: NCS1/Frequenin

Background:

Synonyms: 9430075O15Rik, A730032G13Rik, AI836659, DKFZp761L1223, FLUP, Frequenin, Frequenin homolog Drosophila, Frequenin homolog, Frequenin like protein, Frequenin, Drosophila, homolog of, Frequenin-like protein, Frequenin-like ubiquitous protein, Mfreq, NCS 1, NCS-1, ncs1, NCS1_HUMAN, Neuronal calcium sensor 1, Neuronal Calicum Sensor 1.

Background: NCS-1 (for neuronal calcium sensor-1, also designated frequenin) belongs to a highly conserved family of EF-hand-containing Ca++-binding proteins expressed mainly in neurons. NCS-1 is localized to neuronal cell bodies and axons throughout the brain and spinal cord. It is also expressed in glial cells and in neuroendocrine bovine adrenal chromaffin and PC12 cells. NCS-1 is a regulatory protein involved in Ca++-dependent exocytosis of synaptic vesicles and dense core granules. NCS-1 also functions in the voltage-independent autocrine pathway that negatively regulates non-L-type Ca++ channels.