P2RY14 antibody (AA 125-230) (AbBy Fluor® 488)

Catalog No. ABIN1394740

This Rabbit Polyclonal antibody specifically detects P2RY14 in IF (cc) and IF (p). It exhibits reactivity toward Human.

Quick Overview for P2RY14 antibody (AA 125-230) (AbBy Fluor® 488) (ABIN1394740)

Target: P2RY14 (Purinergic Receptor P2Y, G-Protein Coupled, 14 (P2RY14))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This P2RY14 antibody is conjugated to AbBy Fluor® 488

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-P2RY14 Antibody (AbBy Fluor® 488)

Binding Specificity: AA 125-230

Predicted Reactivity: Human,Mouse,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human G-protein coupled receptor 105

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for P2RY14

Target: P2RY14 (Purinergic Receptor P2Y, G-Protein Coupled, 14 (P2RY14))

Alternative Name: GPR105

Background:

Synonyms: A330108O13Rik, G protein coupled receptor for UDP-glucose, G protein-coupled receptor 105, G protein-coupled receptor VTR 15-20, G-protein coupled receptor 105, GPR105, KIAA0001, P2RY14, P2Y purinoceptor 14, P2Y14 receptor, P2Y14, P2Y14 receptor, P2Y14_HUMAN, Purinergic receptor P2Y G protein coupled 14, Similar to TYPE-1 Angiotensin II receptor, UDP-glucose receptor, GPCR GPR105.

Background: G protein-coupled receptors (GPRs) are a protein family of transmembrane receptors that transmit an extracellular signal (ligand binding) into an intracellular signal (G protein activation). GPR signaling is an evolutionarily ancient mechanism used by all eukaryotes to sense environmental stimuli and mediate cell-cell communication. All of the receptors have seven membrane-spanning domains and the extracellular parts of the receptor can be glycosylated. These extracellular loops also contain two highly conserved cysteine residues which create disulfide bonds to stabilize the receptor structure. GPR105, also designated P2Y14, is widely expressed throughout many brain regions where it localizes to glial cells, and specifically co-localizes with astrocytes. GPR105 is upregulated when a tissue is immunologically challenged with lipopolysaccharide, leading to the theory that GPR105 may play an important role in modulating peripheral and neuroimmune function.