ADRA2C antibody (AA 21-120) (FITC)

Catalog No. ABIN1394816

The Rabbit Polyclonal anti-ADRA2C antibody has been validated for FACS, IF (cc) and IF (p). It is suitable to detect ADRA2C in samples from Human and Mouse.

Quick Overview for ADRA2C antibody (AA 21-120) (FITC) (ABIN1394816)

Target: ADRA2C (Adrenergic, alpha-2C-, Receptor (ADRA2C))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADRA2C antibody is conjugated to FITC

Application: Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-ADRA2C Antibody (FITC)

Binding Specificity: AA 21-120

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Dog,Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ADRA2C/alpha 2C Adrenergic Receptor

Isotype: IgG

Application Details

Application Notes: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for ADRA2C

Target: ADRA2C (Adrenergic, alpha-2C-, Receptor (ADRA2C))

Alternative Name: ADRA2C/alpha 2C Adrenergic Receptor

Background:

Synonyms: Adra 2c, Adra 2c, ADRA2C, ADRA2C, ADRA2L2, ADRA2L2, ADRA2RL2, ADRA2RL2, ADRARL2, ADRARL2, Adrenergic alpha 2C receptor, Adrenoceptor alpha 2C, Alpha 2C adrenergic receptor, Alpha 2C adrenergic receptor subtype C4, Alpha 2C adrenoceptor, Alpha 2C adrenoreceptor, Alpha 2CAR, alpha2 AR C4, alpha2 AR C4, alpha2 C4, alpha2 C4, alpha2C, alpha2C, ALPHA2CAR, alpha2cii-adrenergic receptor, Subtype alpha2 C4, Subtype alpha2 C4, ADA2C_HUMAN.

Background: alpha2C-adrenergic receptors (alpha2C-AR) regulate neurotransmitter release from sympathetic nerves in the heart, and from adrenergic neurons in the central nervous system. alpha2C-AR can influence Parkinson?s disease, panic disorders, and Huntington disease (HD) progression. A genetic variant in the alpha2C-AR coding region (Del322-325) renders the receptor partially uncoupled from Gi, and is a contributing risk factor for heart failure. alpha2C-AR transcripts are present in rat muscle, heart, pancreas, and kidney.

Pathways: EGFR Signaling Pathway, cAMP Metabolic Process