SLC6A7 antibody (AA 151-260) (FITC)

Catalog No. ABIN1395302

The Rabbit Polyclonal anti-SLC6A7 antibody is suitable to detect SLC6A7 in samples from Human. It has been validated for IF (cc) and IF (p).

Quick Overview for SLC6A7 antibody (AA 151-260) (FITC) (ABIN1395302)

Target: SLC6A7 (Solute Carrier Family 6 (Neurotransmitter Transporter, L-Proline), Member 7 (SLC6A7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC6A7 antibody is conjugated to FITC

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-SLC6A7 Antibody (FITC)

Binding Specificity: AA 151-260

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SLC6A7/PROT

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for SLC6A7

Target: SLC6A7 (Solute Carrier Family 6 (Neurotransmitter Transporter, L-Proline), Member 7 (SLC6A7))

Alternative Name: SLC6A7/PROT

Background:

Synonyms: SC6A7_HUMAN, Slc6a7, Sodium-dependent proline transporter, Solute carrier family 6 member 7.

Background: The GAT1 gene family includes sodium- and chloride-dependent plasma membrane transporters for neurotransmitters, metabolites and osmolites, which couple substrate flux to transmembrane electrochemical gradients. PROT (Sodium-dependent proline transporter), also known as Solute carrier family 6 member 7, is a 636 amino acid multi-pass membrane protein that is a GAT1 family member specifically expressed in regions of the brain. PROT terminates the action of proline by its high affinity sodium/chloride-dependent reuptake into pre-synaptic terminals. Enriched in glutamatergic synaptic terminals, it is likely that PROT plays an important role in excitatory events of neurotransmission. PROT-mediated proline uptake is inhibited by compounds such as benztropine, LP-403812 and Des-Tyr-Leu-enkephalin (GGFL). These inhibitors of proline uptake may lead to the development of therapeutic agents for certain neurologic disorders.