STRN3 antibody (AA 75-180) (Biotin)

Catalog No. ABIN1395367

This Rabbit Polyclonal antibody specifically detects STRN3 in ELISA, IHC (p) and IHC (fro). It exhibits reactivity toward Mouse.

Quick Overview for STRN3 antibody (AA 75-180) (Biotin) (ABIN1395367)

Target: STRN3 (Striatin, Calmodulin Binding Protein 3 (STRN3))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STRN3 antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-STRN3 Antibody (Biotin)

Binding Specificity: AA 75-180

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Striatin 3

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for STRN3

Target: STRN3 (Striatin, Calmodulin Binding Protein 3 (STRN3))

Alternative Name: Striatin 3/SG2NA

Background:

Synonyms: Striatin3, Striatin-3, Cell cycle autoantigen SG2NA, Cell cycle S/G2 nuclear autoantigen, GS2NA, nuclear autoantigen, S/G2 antigen, SG2NA, Striatin 3, Striatin, calmodulin binding protein 3, STRN3_HUMAN.

Background: Striatin, SG2NA, and zinedin, the three mammalian members of the striatin family, are multimodular, WD repeat and calmodulin-binding proteins. Zinedin and SG2NA share with striatin identical protein-protein interaction domains and the same overall domain structure. All three proteins are both cytosolic and membrane-bound and bind calmodulin in the presence of calcium. Striatin is a neuronal, intracellular protein strictly expressed in the somato-dendritic compartment, including spines and subsets of neurons, and is considered as a marker of neuronal polarity. Downregulation of striatin, which is expressed in a few subsets of neurons, impairs the growth of dendrites as well as rat locomotor activity. Zinedin is mainly expressed in the central nervous system, whereas SG2NA is mainly expressed in the brain and muscle.

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling