KCNA3 antibody (pTyr135) (AbBy Fluor® 350)

Catalog No. ABIN1395567

The AbBy Fluor® 350-conjugated Rabbit Polyclonal anti-KCNA3 antibody (ABIN1395567) specifically detects KCNA3 in IF (cc) and IF (p). The antibody is reactive with Human samples.

Quick Overview for KCNA3 antibody (pTyr135) (AbBy Fluor® 350) (ABIN1395567)

Target: KCNA3 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 (KCNA3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNA3 antibody is conjugated to AbBy Fluor® 350

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-KCNA3 Antibody (AbBy Fluor® 350)

Binding Specificity: pTyr135

Predicted Reactivity: Human,Mouse,Rat,Cow,Sheep,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human KCNA3 around the phosphorylation site of Tyr135

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for KCNA3

Target: KCNA3 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 (KCNA3))

Alternative Name: KCNA3

Background:

Synonyms: KCNA3 phospho Y135, p-KCNA3 phospho Y135, p-KV1.3 phospho Y135, Potassium Channel Kv1.3, HGK 5, HGK5, HLK 3, HLK3, HPCN 3, HPCN3, HuKIII, KCNA 3, KCNA3, KV1.3, MK 3, MK3, PCN 3, PCN3, Potassium channel 3, Potassium voltage gated channel shaker related subfamily member 3, Potassium voltage gated channel subfamily A member 3, Type n potassium channel, Voltage gated potassium channel subunit Kv1.3, KCNA3_HUMAN.

Background: Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. [provided by RefSeq, Jul 2008].