GRM2 antibody (AbBy Fluor® 350)

Catalog No. ABIN1396544

The Rabbit Polyclonal anti-GRM2 antibody has been validated for IF (p). It is suitable to detect GRM2 in samples from Human, Rat, Mouse, Cow, Dog and Chicken.

Quick Overview for GRM2 antibody (AbBy Fluor® 350) (ABIN1396544)

Target: GRM2 (Glutamate Receptor, Metabotropic 2 (GRM2))

Reactivity: Human, Rat, Mouse, Cow, Dog, Chicken

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRM2 antibody is conjugated to AbBy Fluor® 350

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-GRM2 Antibody (AbBy Fluor® 350)

Cross-Reactivity: Chicken, Cow, Dog, Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GRM2/GLUR2

Isotype: IgG

Application Details

Application Notes: FCM(1:100-500)
IF(IHC-P)(1:100-500)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for GRM2

Target: GRM2 (Glutamate Receptor, Metabotropic 2 (GRM2))

Alternative Name: Metabotropic Glutamate Receptor 2

Background:

Synonyms: Glutamate Receptor Metabotropic 2, Gprc1b, AMPA selective glutamate receptor 2, GLUR 2, GLUR2, GLURB, Glutamate receptor metabotropic 2, Metabotropic Glutamate Receptor 2, GPRC1B, GRM 2, Grm2, mGlu 2, MGlu2, MGLUR 2, Mglur2, GRM2_HUMAN.

Background: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

Molecular Weight: 96kDa

Gene ID: 2912

Pathways: cAMP Metabolic Process, Dicarboxylic Acid Transport