Rhil-18 antibody (AbBy Fluor® 488)

Catalog No. ABIN1397235

The AbBy Fluor® 488-conjugated Rabbit Polyclonal anti-Rhil-18 antibody (ABIN1397235) specifically detects Rhil-18 in WB. The antibody is reactive with Human samples.

Quick Overview for Rhil-18 antibody (AbBy Fluor® 488) (ABIN1397235)

Target: Rhil-18

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: AbBy Fluor® 488

Application: Western Blotting (WB)

Product Details

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human recombinant IL-18-Fc

Isotype: IgG

Application Details

Application Notes: IF(IHC-P): (1:50-200)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: Rhil-18

Background:

Synonyms: rhIL-18-Fc, Iboctadekin,N gamma inducing factor,N-gamma-inducing factor,IG,IL 1 gamma,IL 18,IL 1g,IL-1 gamma,IL-18,IL1 gamma,IL18,IL18 protein,IL18_HUMAN,IL1F4,IL1g,IL1gamma,Interferon gamma inducing factor,Interferon gamma-inducing factor,Interleukin 1 gamma,Interleukin 18,Interleukin-1 gamma,Interleukin-18,Interleukin18,MGC12320.

Background: IL18 (IFN-gamma-inducing factor, IGIF) is a novel pro-inflammatory cytokine that augments natural killer (NK) activity in spleen cells. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity.IL18 also has other biological properties such as stimulation of Fas ligand expression, and induction of CC and CXC chemokines. IL18 increases production of competent HIV. IL18 is related to the IL1 family. One of the IL18 receptor chains is the IL1 receptor-related protein, a member of the IL 1R family. Like IL1 , IL18 is first synthesized as a leaderless precursor requiring the IL1 converting enzyme (ICE) for cleavage into an active molecule. IL18 may play a role in tissue injury in inflammatory reactions.

Gene ID: 3606