ESR2 antibody (pSer87) (AbBy Fluor® 647)

Catalog No. ABIN1397685

This anti-ESR2 antibody is a Rabbit Polyclonal antibody detecting ESR2 in WB. Suitable for Human, Mouse and Rat.

Quick Overview for ESR2 antibody (pSer87) (AbBy Fluor® 647) (ABIN1397685)

Target: ESR2 (Estrogen Receptor 2 (ESR2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ESR2 antibody is conjugated to AbBy Fluor® 647

Application: Western Blotting (WB)

Product Details anti-ESR2 Antibody (AbBy Fluor® 647)

Binding Specificity: pSer87

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Sheep,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human Estrogen Receptor beta around the phosphorylation site of Ser87 [HL(p-S)PL]

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for ESR2

Target: ESR2 (Estrogen Receptor 2 (ESR2))

Alternative Name: Estrogen Receptor beta

Background:

Synonyms: Estrogen Receptor beta phospho S87, Estrogen Receptor beta phospho Ser87, p-ER betaS87, p-ER betaSer87, ER-betaSer87, ER-betaS87, Estrogen receptor-beta, ER BETA, ER-BETA, ER-beta, Erb, ESR 2, ESR 2, ESR B, ESR-B, ESR BETA, ESR-BETA, ESR2, ESR2, ESR2_HUMAN, ESRB, ESTRB, estrogen nuclear receptor beta variant a, estrogen nuclear receptor beta variant b, estrogen receptor 2 ER beta, Estrogen Receptor 2, Estrogen Receptor-2, estrogen receptor beta 4, Estrogen receptor beta, NR3A2, Nuclear receptor subfamily 3 group A member 2.

Background: Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER alpha and ER beta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. ER alpha and ER beta A have been shown to be differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER alpha and ER beta may be regulated by distinct mechanisms even though they share many functional characteristics.

Gene ID: 2100

Pathways: Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling