T-Box 1 antibody (AA 165-270) (AbBy Fluor® 350)

Catalog No. ABIN1398105

This anti-T-Box 1 antibody is a Rabbit Polyclonal antibody detecting T-Box 1 in WB and FACS. Suitable for Human, Mouse and Rat.

Quick Overview for T-Box 1 antibody (AA 165-270) (AbBy Fluor® 350) (ABIN1398105)

Target: T-Box 1 (TBX1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This T-Box 1 antibody is conjugated to AbBy Fluor® 350

Application: Western Blotting (WB), Flow Cytometry (FACS)

Product Details anti-T-Box 1 Antibody (AbBy Fluor® 350)

Binding Specificity: AA 165-270

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TBX1

Isotype: IgG

Application Details

Application Notes: FCM 1:20-100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for T-Box 1

Target: T-Box 1 (TBX1)

Alternative Name: TBX1

Background:

Synonyms: Brachyury, CAFS, CTHM, DGCR, DGS, DORV, T box 1, T box 1 transcription factor, T box 1 transcription factor C, T box, T box protein 1, T box transcription factor TBX 1, T box transcription factor TBX1, T-box 1, T-box protein 1, T-box transcription factor TBX1, TBX 1, TBX 1C, tbx1, TBX1_HUMAN, TBX1C, Testis specic T box protein, Testis-specic T-box protein, TGA, VCFS.

Background: Probable transcriptional regulator involved in developmental processes. Is required for normal development of the pharyngeal arch arteries.Involvement in disease:Haploinsufficiency of the TBX1 gene is responsible for most of the physical malformations present in DiGeorge syndrome (DGS) and velocardiofacial syndrome (VCFS) . DGS is characterized by the association of several malformations: hypoplastic thymus and parathyroid glands, congenital conotruncal cardiopathy, and a subtle but characteristic facial dysmorphology. VCFS is marked by the association of congenital conotruncal heart defects, cleft palate or velar insufficiency, facial dysmorpholgy and learning difficulties. It is now accepted that these two syndromes represent two forms of clinical expression of the same entity manifesting at different stages of life.Defects in TBX1 are a cause of DiGeorge syndrome (DGS) .Defects in TBX1 are a cause of velocardiofacial syndrome (VCFS) .Defects in TBX1 are a cause of conotruncal heart malformations (CTHM). CTHM consist of cardiac outflow tract defects, such as tetralogy of Fallot, pulmonary atresia, double-outlet right ventricle, truncus arteriosus communis, and aortic arch anomalies.

Gene ID: 6899

Pathways: Retinoic Acid Receptor Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Regulation of Muscle Cell Differentiation