Lin28A/ B (AA 75-180) antibody (AbBy Fluor® 350)

Catalog No. ABIN1399119

The AbBy Fluor® 350-conjugated Rabbit Polyclonal anti-Lin28A/ B antibody (ABIN1399119) specifically detects Lin28A/ B in WB, IF (cc) and IF (p). The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Lin28A/ B (AA 75-180) antibody (AbBy Fluor® 350) (ABIN1399119)

Target: Lin28A/ B

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: AbBy Fluor® 350

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details

Binding Specificity: AA 75-180

Specificity: This antibody is produced using synthetic peptide that falls within the range of 90-120 amino acids of human Lin28A. Due to 92 % sequence similarity, this antibody may cross react with Lin28B.

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Lin28A

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: Lin28A/ B

Alternative Name: Lin28A/B

Background:

Synonyms: Protein lin-28 homolog A, LIN28A, Lin-28A, Zinc finger CCHC domain-containing protein 1, CSDD1, LIN28, ZCCHC1, Protein lin-28 homolog B, LIN28B, Lin-28B, CSDD2

Background: LIN-28 is a highly conserved, RNA-binding, cytoplasmic protein. It consists of a cold shock domain and retroviral-type (CCHC) zinc finger motifs that were first identified in Caenorhabditis elegans. LIN-28 controls the timing of events during embryonic development and is readily expressed in embryos, embryonic stem cells and embryonal carcinoma cells. The presence of LIN-28 persists in some adult tissues including cardiac and skeletal muscle. In differentiating myoblasts, LIN-28 increases protein synthesis efficiency and binds to the growth and differentiation factor IGF-II.

Gene ID: 79727, 389421

UniProt: Q6ZN17