HSPB7 antibody (AA 135-170) (AbBy Fluor® 647)

Catalog No. ABIN1402668

The AbBy Fluor® 647-conjugated Rabbit Polyclonal anti-HSPB7 antibody (ABIN1402668) specifically detects HSPB7 in WB and IF (p). The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for HSPB7 antibody (AA 135-170) (AbBy Fluor® 647) (ABIN1402668)

Target: HSPB7 (Heat Shock 27kDa Protein Family, Member 7 (Cardiovascular) (HSPB7))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSPB7 antibody is conjugated to AbBy Fluor® 647

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-HSPB7 Antibody (AbBy Fluor® 647)

Binding Specificity: AA 135-170

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HSPB7/cvHSP

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for HSPB7

Target: HSPB7 (Heat Shock 27kDa Protein Family, Member 7 (Cardiovascular) (HSPB7))

Alternative Name: HSPB7

Background:

Synonyms: cvHSP, Heat shock protein beta-7, HspB7, Cardiovascular heat shock protein

Background: The heat shock proteins (HSPs) comprise a group of highly conserved, abundantly expressed proteins with diverse functions, including the assembly and sequestering of multiprotein complexes, transportation of nascent polypeptide chains across cellular membranes and regulation of protein folding. Heat shock proteins (also known as molecular chaperones) fall into six general families: HSP 90, HSP 70, HSP 60, the small HSPs, the immunophilins and the HSP 110 family. HSPB7 (heat shock 27 kDa protein family, member 7), also known as cvHSP (cardiovascular heat shock protein) or Heat shock protein beta-7, is a member of the small HSP (sHSP) family expressed in heart and skeletal muscle. Members of the sHSP family contain a conserved C-terminal ?crystallin domain and typically function in homo- or heteromeric complexes. The sHSPs bind to denatured proteins and are responsible for preventing the aggregation of these proteins. In response to muscle fiber transformation and in muscular dystrophy, the expression levels of HSPB7 are drastically increased, suggesting that HSPB7 may be a useful target in therapeutic strategies for preventing age-related muscle wasting.

Gene ID: 27129

UniProt: Q9UBY9