HOPX antibody (AA 25-73) (Biotin)

Catalog No. ABIN1402855

This Rabbit Polyclonal antibody specifically detects HOPX in WB and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for HOPX antibody (AA 25-73) (Biotin) (ABIN1402855)

Target: HOPX (HOP Homeobox (HOPX))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HOPX antibody is conjugated to Biotin

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-HOPX Antibody (Biotin)

Binding Specificity: AA 25-73

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HOPX/LAGY

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for HOPX

Target: HOPX (HOP Homeobox (HOPX))

Alternative Name: LAGY

Background:

Synonyms: HOD, HOP, OB1, LAGY, TOTO, CAMEO, NECC1, SMAP31, Homeodomain-only protein, Lung cancer-associated Y protein, Not expressed in choriocarcinoma protein 1, Odd homeobox protein 1, HOPX

Background: Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor.

Gene ID: 84525

UniProt: Q9BPY8

Pathways: Regulation of Muscle Cell Differentiation