EPR1 antibody (Biotin)

Catalog No. ABIN1403125

This Rabbit Polyclonal antibody specifically detects EPR1 in WB and IHC (p). It exhibits reactivity toward Human.

Quick Overview for EPR1 antibody (Biotin) (ABIN1403125)

Target: EPR1 (Early-Phytochrome-Responsive1 (EPR1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPR1 antibody is conjugated to Biotin

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-EPR1 Antibody (Biotin)

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human EPR1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for EPR1

Target: EPR1 (Early-Phytochrome-Responsive1 (EPR1))

Alternative Name: EPR1

Background:

Synonyms: Effector cell peptidase receptor 1, Effector cell protease receptor 1, EPR 1, EPR1, EPR-1.

Background: Cellular receptors for blood proteases regulate chemotaxis, extracellular proteolysis, and growth behavior of normal and malignant cells. Effector cell protease receptor-1 (EPR1) is a receptor for the coagulation protease factor Xa. EPR1 is characterized by a cysteine-rich extracellular module, a single membrane-spanning domain, and a serine-rich cytoplasmic tail featuring at least 15 potential phosphorylation sites. EPR1 also contains 2 N-linked glycosylation sites, 4 O-linked glycosylation sites, and a chondroitin sulfate attachment site, which may provide anchoring for carbohydrate chains, EPR1 transfectants bind to factor Xa in a specific and saturable manner, and in the absence of factor V/Va promote prothrombin activation in a factor Xa concentration-dependent reaction. Activated platelets and megakaryocytes express EPR1. Both EPR1 and membrane-bound factor Va are thought to be required to mediate factor Xa binding to the activated platelet to form a functional prothrombinase complex.

Gene ID: 8475

Pathways: Apoptosis, Cell Division Cycle