ANGEL1 antibody (Biotin)

Catalog No. ABIN1404397

This Rabbit Polyclonal antibody specifically detects ANGEL1 in WB and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for ANGEL1 antibody (Biotin) (ABIN1404397)

Target: ANGEL1 (Angel Homolog 1 (ANGEL1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ANGEL1 antibody is conjugated to Biotin

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-ANGEL1 Antibody (Biotin)

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ANGEL1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for ANGEL1

Target: ANGEL1 (Angel Homolog 1 (ANGEL1))

Alternative Name: ANGEL1

Background:

Synonyms: ANGE1_HUMAN, ANGEL1, KIAA0759, mKIAA0759, Protein angel homolog 1, angel homolog 1, RGD1306238.

Background: ANGEL1 , also known as KIAA0759, is a 670 amino acid protein belonging to the CKR-4 protein family. ANGEL1 is encoded by a gene located on human chromosome 14, which contains about 700 genes and 106 million base pairs, making up about 3.5 % of human cellular DNA. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of three key genes associated with the development of Alzheimer's disease. The SERPINA1 gene is located on chromosome 14 and, when defective, leads to the genetic disorder ?-antitrypsin deficiency. This disorder is characterized by severe lung complications and liver dysfunction. Notably, the immunoglobulin heavy chain locus on chromosome 14 and its fusion via translocation with the chromosome 19 encoded protein BCL3 may be related to B-cell malignancies.

Gene ID: 23357