Membralin antibody (AA 161-260) (Cy5.5)

Catalog No. ABIN1408475

The Rabbit Polyclonal anti-Membralin antibody has been validated for WB, IF (cc) and IF (p). It is suitable to detect Membralin in samples from Zebrafish (Danio rerio).

Quick Overview for Membralin antibody (AA 161-260) (Cy5.5) (ABIN1408475)

Target: Membralin (TMEM259) (Transmembrane Protein 259 (TMEM259))

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Membralin antibody is conjugated to Cy5.5

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-Membralin Antibody (Cy5.5)

Binding Specificity: AA 161-260

Cross-Reactivity: Zebrafish (Danio rerio)

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Membralin

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Membralin

Target: Membralin (TMEM259) (Transmembrane Protein 259 (TMEM259))

Alternative Name: Membralin/C19orf6

Background:

Synonyms: ASBABP1, C19orf6, MGC4022, R32184_3, aspecic BCL2 ARE-binding protein 1, C19orf6, chromosome 19 open reading frame 6, MBRL, MBRL_HUMAN.

Background: The gene encoding human Membralin, C19orf6, localizes to chromosome 19p13.3. It contains 11 exons, which encode at least two splice variants in human cancer. Membralin is a multi-pass membrane protein and exists either as a long or short form. The long form of Membralin comprises all 11 exons, while the short form contains all exons except exon 10. Expression of different Membralin isoforms depends on tissue type. The long form is expressed in ovarian and colorectal carcinomas, whereas the short form is expressed in breast or pancreatic carcinomas. Because Membralin expression in ovarian carcinomas is highest in serous carcinomas as compared to surface epithelium carcinomas, expression of Membralin may be useful as a novel tumor-associated marker in ovarian serous carcinomas.