Membralin antibody (Middle Region)

Catalog No. ABIN2778282

The Rabbit Polyclonal anti-Membralin antibody (ABIN2778282) specifically detects Membralin in WB and IHC. The antibody is reactive with Human, Guinea Pig, Rat, Dog, Mouse, Cow and Zebrafish (Danio rerio) samples.

Quick Overview for Membralin antibody (Middle Region) (ABIN2778282)

Target: Membralin (TMEM259) (Transmembrane Protein 259 (TMEM259))

Reactivity: Human, Guinea Pig, Rat, Dog, Mouse, Cow, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Membralin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Membralin Antibody

Binding Specificity: Middle Region

Purpose: C19ORF6 Antibody - middle region

Sequence: YDDILMSSVK GLAENEENKG FLRNVVSGEH YRFVSMWMAR TSYLAAFAIM

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against C19ORF6. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human C19ORF6

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8114519

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for Membralin

Target: Membralin (TMEM259) (Transmembrane Protein 259 (TMEM259))

Alternative Name: C19ORF6

Background:

Background Information: Human membralin is unique and does not share significant sequence homology with other human genes, only membralins of other species. The membralin gene contains 11 exons which encode at least two spliced variants in human cancer. The long form of membralin (membralin-1) comprises all 11 exons, encoding a protein of 620-amino acids long and the short form of membralin (membralin-3) contains all exons except for exon 10, encoding a protein of 408 amino acids. Expression of different membralin isoforms depends on tissue type. The long form, membralin-1, is expressed in ovarian and colorectal carcinomas but not in breast or pancreatic carcinomas, which express only the short splice form, membralin-3. Recent studies suggest that membralin is a novel tumor-associated marker in ovarian serous carcinomas

Gene Name: Chromosome 19 open reading frame 6

Alternative Symbols: MBRL, ASBABP1, C19orf6, R32184_3, MEMBRALIN

Protein Name: Membralin

Molecular Weight: 46kDa

Gene ID: 91304

NCBI Accession: NP_219488

UniProt: Q4ZIN3