Synaptojanin 2 antibody (AA 401-500) (HRP)

Catalog No. ABIN1408808

The Rabbit Polyclonal anti-Synaptojanin 2 antibody has been validated for WB, ELISA, IHC (fro) and IHC (p). It is suitable to detect Synaptojanin 2 in samples from Human.

Quick Overview for Synaptojanin 2 antibody (AA 401-500) (HRP) (ABIN1408808)

Target: Synaptojanin 2 (SYNJ2)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Synaptojanin 2 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Synaptojanin 2 Antibody (HRP)

Binding Specificity: AA 401-500

Predicted Reactivity: Human,Mouse,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Synaptojanin 2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Synaptojanin 2

Target: Synaptojanin 2 (SYNJ2)

Alternative Name: Synaptojanin 2

Background:

Synonyms: 5-trisphosphate 5-phosphatase 2, Inositol phosphate 5' phosphatase 2, INPP 5H, INPP5H, KIAA0348, MGC44422, SJ2, Synaptic inositol 1 4 5 trisphosphate 5 phosphatase 2, Synaptic inositol-1, Synaptojanin-2, Synaptojanin2, SYNJ 2, Synj2, SYNJ2_HUMAN.

Background: The inositol polyphosphate 5-phosphatases selectively remove the phosphate from the 5-position of various phosphatidylinositols, which generate second messengers in response to extracellular signals. Synaptojanins are characterized by an N-terminal SAC1-like sequence, a central 5-phosphate domain, and a unique C-terminal sequence and have been shown to use phosphatidylinositol 4,5-bisphosphate as a substrate. Synaptojanins exist as two isoforms, synaptojanin 1 and 2, which differ in the C-terminal domain, and each isoform has multiple variants produced by alternative splicing. Synaptojanin 1 is expressed as two major forms: the shorter is found in brain while the longer is expressed in peripheral tissues. Eight splice variants of synaptojanin 2 have been detected, including a brain specific isoform. Synaptojanins are thought to participate in the endocytosis of synaptic vesicles and the regulation of the actin cytoskeleton.

Gene ID: 8871

Pathways: Inositol Metabolic Process