NAV1 antibody (AA 1426-1475) (HRP)

Catalog No. ABIN1409336

The Rabbit Polyclonal anti-NAV1 antibody has been validated for WB, ELISA, IHC (fro) and IHC (p). It is suitable to detect NAV1 in samples from Human.

Quick Overview for NAV1 antibody (AA 1426-1475) (HRP) (ABIN1409336)

Target: NAV1 (Neuron Navigator 1 (NAV1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NAV1 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-NAV1 Antibody (HRP)

Binding Specificity: AA 1426-1475

Predicted Reactivity: Human,Mouse,Rat,Dog,Pig,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Neuron navigator 1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for NAV1

Target: NAV1 (Neuron Navigator 1 (NAV1))

Alternative Name: Neuron navigator 1

Background:

Synonyms: Nav 1, Nav1, POMFIL 3, POMFIL3, Pore membrane and/or filament interacting like protein 3, Protein Steerin 1, Protein Steerin1, Steerin 1, Steerin1, unc-53 homolog 1, DKFZp781D0314, FLJ12560, FLJ14203, mNav1, NAV1_HUMAN.

Background: Neuron navigator 1 is a 1877 amino acid cytoplasmic protein that is involved in neuronal migration. Neuron navigtor 1 is widely expressed at low levels, though highest expression is found in both adult and fetal nervous tissue. Through interaction with tubulin, Neuron navigator 1 associates with a subset of mirotubule plus ends present in the growth cone. Overexpression of Neuron navigator 1 leads to microtubule bundling, whereas a reduction of its levels causes loss of directionality in the migration of pontine cell leading processes. There are seven isoforms of Neuron navigator 1 that are produced as a result of alternative splicing events.