RCAN1 antibody (AA 101-200) (HRP)

Catalog No. ABIN1409774

The Rabbit Polyclonal anti-RCAN1 antibody has been validated for WB, ELISA, IHC (p) and IHC (fro). It is suitable to detect RCAN1 in samples from Human.

Quick Overview for RCAN1 antibody (AA 101-200) (HRP) (ABIN1409774)

Target: RCAN1 (Regulator of Calcineurin 1 (RCAN1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RCAN1 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-RCAN1 Antibody (HRP)

Binding Specificity: AA 101-200

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Calcipressin 1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for RCAN1

Target: RCAN1 (Regulator of Calcineurin 1 (RCAN1))

Alternative Name: Calcipressin 1/DSCR 1

Background:

Synonyms: Adapt 78, Adapt78, Calcipressin 1, Calcipressin-1, Calcium and oxidant inducible mRNA, CSP 1, CSP1, Down syndrome candidate region 1, Down syndrome critical region gene 1, Down syndrome critical region protein 1, DSC 1, DSC1, DSCR 1, DSCR1, DSCR-1, MCIP 1, MCIP1, Modulatory calcineurin interacting protein 1, Myocyte enriched calcineurin interacting protein 1, Myocyte-enriched calcineurin-interacting protein 1, Near DSCR proline rich protein, RCAN1, RCAN1_HUMAN, RCN 1, RCN1, Regulator of calcineurin 1.

Background: DSCR1 protein influences cardiac and nervous system development (1). DSCR1 is abundant in the brain, heart, and skeletal muscle. Overexpression of DSCR1 may play a role in the pathogenesis of Down syndrome, in particular mental retardation and/or cardiac defects. DSCR1 inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Human DSCR1 maps to gene locus 21q22.1-q22.2.

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development