GSX1/GSH1 antibody (AA 165-264) (HRP)

Catalog No. ABIN1410200

The Rabbit Polyclonal anti-GSX1/GSH1 antibody has been validated for ELISA, WB, IHC (fro) and IHC (p). It is suitable to detect GSX1/GSH1 in samples from Mouse.

Quick Overview for GSX1/GSH1 antibody (AA 165-264) (HRP) (ABIN1410200)

Target: GSX1/GSH1 (GSX1) (GS Homeobox 1 (GSX1))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GSX1/GSH1 antibody is conjugated to HRP

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-GSX1/GSH1 Antibody (HRP)

Binding Specificity: AA 165-264

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Sheep,Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Gsh1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for GSX1/GSH1

Target: GSX1/GSH1 (GSX1) (GS Homeobox 1 (GSX1))

Alternative Name: Gsh1

Background:

Synonyms: GS homeo box protein 1, GS homeobox 1, GSH1, GSX1, GSX1_HUMAN, Homeobox protein GSH-1 , Homeobox protein Gsh1.

Background: Growth hormone-releasing hormone (GHRH) stimulates secretion and synthesis of growth hormone (GH), causes somatotroph proliferation and may have direct actions in fetal/placental development, reproduction and immune function. It exerts its action through high-affinity GHRH receptors present in the anterior pituitary. GSH-1 (GS homeobox 1) is a 264 amino acid hypothalamic nuclear protein that functions as a transcription factor responsible for maintaining GHRH expression as well as playing an important role in pituitary development. Coexpression of CBP leads to significantly enhanced GSH-1-induced GHRH expression, which suggest that CBP may function as a co-activator. Knockdown of GSH-1 mRNA in mice causes a dwarf phenotype, which suggests that certain cases of familial dwarfism may be caused by a mutation of the GSH-1 gene.