Calsyntenin 1 antibody (AA 501-600) (HRP)

Catalog No. ABIN1410386

The Rabbit Polyclonal anti-Calsyntenin 1 antibody has been validated for WB, ELISA, IHC (p) and IHC (fro). It is suitable to detect Calsyntenin 1 in samples from Human.

Quick Overview for Calsyntenin 1 antibody (AA 501-600) (HRP) (ABIN1410386)

Target: Calsyntenin 1 (CLSTN1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Calsyntenin 1 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-Calsyntenin 1 Antibody (HRP)

Binding Specificity: AA 501-600

Predicted Reactivity: Human,Mouse,Rat,Dog,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Calsyntenin 1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Calsyntenin 1

Target: Calsyntenin 1 (CLSTN1)

Alternative Name: CLSTN1/Calsyntenin 1

Background:

Synonyms: Alc alpha, Alc-alpha, Alcadein alpha 1, Alcadein alpha, Alcadein-alpha, alcalpha1, alcalpha2, Alzheimer related cadherin like protein, Alzheimer-related cadherin-like protein, Calsyntenin-1, Calsyntenin1, CLSTN 1, Clstn1, CS1, CSTN1, CSTN1_HUMAN, CTF1-alpha, FLJ32258, KIAA0911, Non classical cadherin XB31alpha, Non-classical cadherin XB31alpha, PIK3CD, SAlc-alpha, XB31alpha.

Background: Members of the calsyntenin protein family are localized to the post-synaptic membrane of exicitatory central nervous system (CNS) synapses. Calsyntenin-1, also known as CSTN1, PIK3CD, Alzheimer-related cadherin-like protein, non-classical cadherin XB31alpha, KIAA0911, ALC-ALPHA, alcalpha1, alcalpha2 or FLJ32258, is a 981 amino acid single-pass type I membrane protein that localizes to the membrane of endoplasmic reticulum, Golgi apparatus, cell projections and postsynaptic cells. Expressed in brain, calsyntenin-1 is also found at lower levels in placenta, skeletal muscle, heart and kidney. Calsyntenin-1 binds synaptic Ca2+ with its cytoplasmic domain and plays a role in extracellular proteolysis. Calsyntenin-1 is also known to form a complex with X11 Beta and APP to suppress the metabolic cleavage of APP, and docks vesicular cargo to KLC1. Calsyntenin-1 may be related to the development or progression of Alzheimer?s disease, and two calsyntenin-1 isoforms are produced as a result of alternative splicing events.