Receptor Accessory Protein 1 antibody (AA 53-150) (Cy3)

Catalog No. ABIN1411005

This anti-Receptor Accessory Protein 1 antibody is a Rabbit Polyclonal antibody detecting Receptor Accessory Protein 1 in WB, IF (cc) and IF (p). Suitable for Mouse.

Quick Overview for Receptor Accessory Protein 1 antibody (AA 53-150) (Cy3) (ABIN1411005)

Target: Receptor Accessory Protein 1 (REEP1)

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Receptor Accessory Protein 1 antibody is conjugated to Cy3

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-Receptor Accessory Protein 1 Antibody (Cy3)

Binding Specificity: AA 53-150

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human REEP1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Receptor Accessory Protein 1

Target: Receptor Accessory Protein 1 (REEP1)

Alternative Name: REEP1

Background:

Synonyms: C2orf23, Chromosome 2 open reading frame 23, FLJ13110, Receptor accessory protein 1, Receptor expression-enhancing protein 1, Reep1, REEP1_HUMAN, SPG31.

Background: Transport of G protein-coupled receptors (GPCRs) to the cell surface membrane is critical for receptor-ligand recognition. Mammalian GPCR odorant receptors (ORs), when heterologously expressed in cells, are poorly expressed on the cell surface. REEP1 (receptor expression-enhancing protein 1), is a 201 amino acid multi-pass mitochondrion membrane protein that belongs to the DP1 family. REEP1 interacts with odorant receptor proteins and may enhance the cell surface expression of odorant receptors. Mutations in the REEP1 gene are the third most common cause of hereditary spastic paraplegia (HSP) after spastin and atlastin gene mutations. Mutations in the REEP1 gene also cause spastic paraplegia autosomal dominant type 31, a neurodegenerative disorder. The REEP1 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, A.thaliana and rice, and maps to human chromosome 2p11.2.