GDF6 antibody (AA 336-410) (HRP)

Catalog No. ABIN1411550

The Rabbit Polyclonal anti-GDF6 antibody has been validated for WB, ELISA, IHC (p) and IHC (fro). It is suitable to detect GDF6 in samples from Human and Rat.

Quick Overview for GDF6 antibody (AA 336-410) (HRP) (ABIN1411550)

Target: GDF6 (Growth Differentiation Factor 6 (GDF6))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GDF6 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-GDF6 Antibody (HRP)

Binding Specificity: AA 336-410

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Dog,Cow,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GDF6

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for GDF6

Target: GDF6 (Growth Differentiation Factor 6 (GDF6))

Alternative Name: GDF6

Background:

Synonyms: bmp 13, bmp13, bmp-13, Cartilage Derived Morphogenetic Protein 2, cdmp 2, CDMP2, gdf 6, GDF16 , Growth dferentiation factor 6, Growth/dferentiation factor 6, GDF6_HUMAN.

Background: Growth/differentiation factors (GDFs) are members of the TGF superfamily (1,2). Members of the TGF superfamily are involved in embryonic development and adult tissue homeostasis (1). GDF-1 expression is almost exclusively restricted to the central nervous system and mediates cell differentiation events during embryonic development (3). Neither GDF-3 (Vgr-2) nor GDF-9 contains the conserved cysteine residue which is found in most other TGF superfamily members. GDF-3 is detectable in bone marrow, spleen, thymus and adipose tissue, whereas GDF-9 has only been detected in ovary (4). GDF-5 (also designated CDMP-1) has been shown to induce activation of plasminogen activator, thereby inducing angiogenesis. It is predominantly expressed in long bones during fetal embryonic development and is involved in bone formation. (5). GDF-5 mutations have been identified in mice with the mutation brachypodism (bp), a mutation which affects the length and number of bones in limbs (6). GDF-6 and GDF-7 are closely related to GDF-5 (6). GDF-8 has been shown to be a negative regulator of skeletal muscle mass (1).