RAB3GAP2 antibody (AA 741-850) (HRP)

Catalog No. ABIN1412102

The Rabbit Polyclonal anti-RAB3GAP2 antibody has been validated for ELISA, IHC (p) and IHC (fro). It is suitable to detect RAB3GAP2 in samples from Human.

Quick Overview for RAB3GAP2 antibody (AA 741-850) (HRP) (ABIN1412102)

Target: RAB3GAP2 (RAB3 GTPase Activating Protein Subunit 2 (Non-Catalytic) (RAB3GAP2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAB3GAP2 antibody is conjugated to HRP

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-RAB3GAP2 Antibody (HRP)

Binding Specificity: AA 741-850

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RAB3GAP2

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for RAB3GAP2

Target: RAB3GAP2 (RAB3 GTPase Activating Protein Subunit 2 (Non-Catalytic) (RAB3GAP2))

Alternative Name: RAB3GAP2

Background:

Synonyms: DKFZp434D245, FLJ14579, KIAA0839, p150, Rab3 GAP p150, Rab3 GAP regulatory subunit, Rab3 GAP150, Rab3 GTPase activating protein 150 kDa subunit, Rab3 GTPase activating protein non catalytic subunit, RAB3 GTPase activating protein subunit 2 non catalytic, RAB3 GTPase activating protein subunit 2, RAB3GAP150, RGAP iso, RP11 568G11.1, RBGPR_HUMAN.

Background: ab 3 GAP p150 is a ubiquitously expressed protein that contains 1,393 amino acids and belongs to the Rab3-GAP regulatory subunit family. Defects in Rab 3 GAP p150 are the cause of Martsolf and Warburg Micro syndrome. Both syndromes are characterized by congenital cataracts, microphthalmia, postnatal microcephaly and developmental delay, and are inherited in an autosomal recessive manner. The Rab3 GTPase-activating complex is a heterodimer composed of RAB3GAP and Rab 3 GAP p150 that interacts with DMXL2. Existing as two alternatively spliced isoforms, the Rab 3 GAP p150 gene is conserved in chimpanzee, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, A.thaliana and rice. The Rab 3 GAP p150 gene contains 36 exons and maps to human chromosome 1q41.