SORCS2 antibody (AA 201-300) (Cy5.5)

Catalog No. ABIN1412243

The Rabbit Polyclonal anti-SORCS2 antibody is suitable to detect SORCS2 in samples from Human. It has been validated for WB, IF (cc) and IF (p).

Quick Overview for SORCS2 antibody (AA 201-300) (Cy5.5) (ABIN1412243)

Target: SORCS2 (Sortilin-Related VPS10 Domain Containing Receptor 2 (SORCS2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SORCS2 antibody is conjugated to Cy5.5

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-SORCS2 Antibody (Cy5.5)

Binding Specificity: AA 201-300

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SORCS2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for SORCS2

Target: SORCS2 (Sortilin-Related VPS10 Domain Containing Receptor 2 (SORCS2))

Alternative Name: SORCS2

Background:

Synonyms: KIAA1329, SORCS 2, Sortilin related VPS10 domain containing receptor 2, VPS10 domain receptor protein, VPS10 domain receptor protein SORCS 2, SORC2_HUMAN.

Background: There are three SorCS genes that have diverse, partially overlapping functions in the central nervous system. In the developing and mature central nervous system, SorCS1, SorCS2 and SorCS3 genes are expressed in a combinatorial, non-overlapping pattern. SorCS proteins show homology to the mosaic receptor SorLA and the neurotensin receptor sortilin, based on a common VPS10 domain, which is the hallmark of the SorCS receptor family. SorCS2 (sortilin-related VPS10 domain containing receptor 2) is a 1,150 amino acid single-pass type I membrane protein that is highly expressed in brain and kidney. Containing six BNR repeats and a single PKD domain, SorCS2 is encoded by a gene that maps to human chromosome 4, which encodes nearly 6 % of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes.