Metabotropic Glutamate Receptor 3 antibody (AA 365-460) (HRP)

Catalog No. ABIN1412540

The Rabbit Polyclonal anti-Metabotropic Glutamate Receptor 3 antibody has been validated for WB and ELISA. It is suitable to detect Metabotropic Glutamate Receptor 3 in samples from Mouse.

Quick Overview for Metabotropic Glutamate Receptor 3 antibody (AA 365-460) (HRP) (ABIN1412540)

Target: Metabotropic Glutamate Receptor 3 (GRM3) (Glutamate Receptor, Metabotropic 3 (GRM3))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Metabotropic Glutamate Receptor 3 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA

Product Details anti-Metabotropic Glutamate Receptor 3 Antibody (HRP)

Binding Specificity: AA 365-460

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Cow,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Metabotropic Glutamate Receptor 3

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Metabotropic Glutamate Receptor 3

Target: Metabotropic Glutamate Receptor 3 (GRM3) (Glutamate Receptor, Metabotropic 3 (GRM3))

Alternative Name: MGLUR3

Background:

Synonyms: G protein coupled receptor family C group 1 member C, GLUR 3, GLUR3, GLUR3, Glutamate metabotropic receptor 3, Glutamate receptor metabotropic 3, GPRC1C, GRM 3, GRM3, GRM3_HUMAN, Metabotropic glutamate receptor 3, Metabotropic glutamate receptor 3 precursor, mGlu 3, MGlu3, MGlu3, MGLUR 3, MGLUR3.

Background: Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to -7. The kainate/AMPA receptors are primarily responsible for the fast excitatory neuro-transmission by glutamate whereas the NMDA receptors are functionally characterized by a slow kinetic and a high permeability for Ca2+ ions. The NMDA receptors consist of five subunits: epsilion 1, 2, 3, 4 and one zeta subunit. The zeta subunit is expressed throughout the brainstem whereas the four epsilon subunits display limited distribution.

Pathways: cAMP Metabolic Process, Synaptic Membrane