UNCX antibody (AA 145-150) (Cy5)

Catalog No. ABIN1412722

This Rabbit Polyclonal antibody specifically detects UNCX in WB, IF (cc) and IF (p). It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for UNCX antibody (AA 145-150) (Cy5) (ABIN1412722)

Target: UNCX (UNC Homeobox (UNCX))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UNCX antibody is conjugated to Cy5

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-UNCX Antibody (Cy5)

Binding Specificity: AA 145-150

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Pig,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human UNCX

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for UNCX

Target: UNCX (UNC Homeobox (UNCX))

Alternative Name: UNCX

Background:

Synonyms: Homeobox protein unc-4 homolog, Homeobox protein Uncx4.1, tcag7.1272, UNC homeobox, Unc4.1 homeobox, UNC4_HUMAN, Uncx, UNCX4.1.

Background: Members of the paired homeobox family play a role in regulating cell development and pattern formation during embryonic stages. UNCX (UNC homeobox), also known as UNCX4.1, is a 531 amino acid nuclear transcription factor involved in neurogenesis and somitogenesis. Containing one homeobox DNA-binding domain, UNCX belongs to the paired homeobox family and UNC4 subfamily. UNCX assists in the formation of connections between hypothalamic neurons and the pituitary, which is necessary for central neurons to deliver hormones into peripheral blood. UNCX also plays a role in maintaining differentiation of the axial skeleton and acts upstream of Pax-9. The gene encoding UNCX maps to human chromosome 7, which houses over 1,000 genes and comprises nearly 5 % of the human genome. Chromosome 7 has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome.