Phospholipase C beta 1 antibody (AA 441-540) (HRP)

Catalog No. ABIN1415619

This anti-Phospholipase C beta 1 antibody is a Rabbit Polyclonal antibody detecting Phospholipase C beta 1 in WB, ELISA, IHC (fro) and IHC (p). Suitable for Human and Rat.

Quick Overview for Phospholipase C beta 1 antibody (AA 441-540) (HRP) (ABIN1415619)

Target: Phospholipase C beta 1 (PLCB1) (phospholipase C, beta 1 (phosphoinositide-Specific) (PLCB1))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Phospholipase C beta 1 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Phospholipase C beta 1 Antibody (HRP)

Binding Specificity: AA 441-540

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Dog,Cow,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Phospholipase C beta 1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Phospholipase C beta 1

Target: Phospholipase C beta 1 (PLCB1) (phospholipase C, beta 1 (phosphoinositide-Specific) (PLCB1))

Alternative Name: Phospholipase C beta 1

Background:

Synonyms: 1-phosphatidylinositol-45-bisphosphate phosphodiesterase beta 1, 1vphosphatidylinositol 4,5 bisphosphate phosphodiesterase beta 1 , Phosphb, Phosphoinositide phospholipase C, Phosphoinositide phospholipase C-beta 1, Phospholipase C beta 1 phosphoinositide-specic, Phospholipase C I, PI PLC, PLC 1, PLC_1, PLC-154, PLC-beta-1, PLC-I, PLC154, Plcb, PLCB1, Plcb1 protein, PLCbeta1.

Background: Phospholipase C beta 1 catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. Its gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for its gene.

Gene ID: 23236

Pathways: WNT Signaling, AMPK Signaling, Thyroid Hormone Synthesis, Inositol Metabolic Process, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, Proton Transport, Skeletal Muscle Fiber Development, CXCR4-mediated Signaling Events, G-protein mediated Events