C12ORF23 antibody (AA 68-116) (Cy7)

Catalog No. ABIN1415677

This Rabbit Polyclonal antibody specifically detects C12ORF23 in IF (cc) and IF (p). It exhibits reactivity toward Human.

Quick Overview for C12ORF23 antibody (AA 68-116) (Cy7) (ABIN1415677)

Target: C12ORF23 (Chromosome 12 Open Reading Frame 23 (C12ORF23))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C12ORF23 antibody is conjugated to Cy7

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-C12ORF23 Antibody (Cy7)

Binding Specificity: AA 68-116

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human C12orf23

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for C12ORF23

Target: C12ORF23 (Chromosome 12 Open Reading Frame 23 (C12ORF23))

Alternative Name: C12orf23

Background:

Synonyms: C12orf23, Chromosome 12 open reading frame 23, CL023_HUMAN, MGC17943, UPF0444 transmembrane protein C12orf23.

Background: C12orf23 (chromosome 12 open reading frame 23), also known as FLJ11721, FLJ13959 or MGC17943, is a 116 amino acid multi-pass membrane protein belonging to the UPF0444 family. C12orf23 is encoded by a gene located on human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5 % of the human genome. Chromosome 12 is associated with a number of skeletal deformities, including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Noonan syndrome, which includes heart and facial developmental defects among the primary symptoms, is caused by a mutant form of PTPN11 gene product, SH-PTP2. Chromosome 12 is also home to a homeobox gene cluster which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster encoding C-type lectin proteins which mediate the NK cell response to MHC I interaction. Trisomy 12p leads to facial development defects, seizure disorders and a host of other symptoms varying in severity depending on the extent of mosaicism and is most severe in cases of complete trisomy.

Gene ID: 90488