DPYSL2 antibody (pSer518, pThr514) (Cy5)

Catalog No. ABIN1416072

This anti-DPYSL2 antibody is a Rabbit Polyclonal antibody detecting DPYSL2 in IF (cc) and IF (p). Suitable for Human, Mouse and Rat.

Quick Overview for DPYSL2 antibody (pSer518, pThr514) (Cy5) (ABIN1416072)

Target: DPYSL2 (Dihydropyrimidinase-Like 2 (DPYSL2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DPYSL2 antibody is conjugated to Cy5

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-DPYSL2 Antibody (Cy5)

Binding Specificity: pSer518, pThr514

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Cow,Sheep,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human CRMP2 around the phosphorylation site of Thr514+Ser518

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for DPYSL2

Target: DPYSL2 (Dihydropyrimidinase-Like 2 (DPYSL2))

Alternative Name: CRMP2+

Background:

Synonyms: CRMP2 phospho T514 + S518, CRMP2 phospho T514+S518, CRMP-2phospho Thr514+S518, p-CRMP2Thr514+S518, CRMP2/Dpysl2DRP 2, Collapsin response mediator protein 2, Collapsin response mediator protein hCRMP 2, CRAM, CRMP 2, DHPRP 2, DHPRP2, Dihydr pyrimidinase 2, Dihydropyrimidinase 2, Dihydropyrimidinase like 2, Dihydropyrimidinase like 2 long form,Dihydropyrimidinase related protein 2, DPYL 2, DPYL2, DPYSL 2, DPYSL2, DRP 2, DRP2, Musunc 33, Musunc33, N2A3, TOAD 64, TOAD64, ULIP 2 protein, Ulip2.

Background: Collapsin response mediator proteins (CRMPs) are cytosolic phosphoproteins involved in neuronal differentiation and axonal guidance. CRMP2 was previously shown to mediate the repulsive effect of Sema3A on axons and to participate in axonal specification. The CRMPs appear to play a complex role in axon growth as well as microtubule dynamics and axon induction. CRMPs localize to the lamellipodia and filopodia of axonal growth cones, suggesting a role in axon guidance. Moreover, CRMP2 is upregulated after axotomy, and appears to increase the formation of axon-type processes from hippocampal neurons. CRMP2 has been reported to bind tubulin dimers directly and modulate microtubule assembly. CRMPs have also been implicated in the pathogenesis of a paraneoplastic neurologic syndrome. Interaction studies have implicated phospholipase D2 (PLD2), the cytosolic tyrosine kinase Fes, and intersectin in CRMP function. Hyperphosphorylation of CRMP2 is an early event in the progression of Alzheimer's disease.

Gene ID: 1808

Pathways: Regulation of Cell Size