DPYS antibody (AA 121-220) (HRP)

Catalog No. ABIN1416094

This Rabbit Polyclonal antibody specifically detects DPYS in WB, ELISA, IHC (p) and IHC (fro). It exhibits reactivity toward Human.

Quick Overview for DPYS antibody (AA 121-220) (HRP) (ABIN1416094)

Target: DPYS (Dihydropyrimidinase (DPYS))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DPYS antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-DPYS Antibody (HRP)

Binding Specificity: AA 121-220

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DHP/Dihydropyrimidinase

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for DPYS

Target: DPYS (Dihydropyrimidinase (DPYS))

Alternative Name: Dihydropyrimidinase

Background:

Synonyms: DHP, DHPase, Dihydropyrimidinase, Dihydropyrimidine amidohydrolase, Dpys, DPYS_HUMAN, Hydantoinase.

Background: Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyzes the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate.Tissue specificity:Liver and kidney.Involvement in disease:Defects in DPYS are the cause of dihydropyrimidinase deficiency (DHPD). DHPD is an autosomal recessive disorder characterized by dihydropyrimidinuria and associated with a variable clinical phenotype: epileptic or convulsive attacks, dysmorphic features and severe developmental delay, and congenital microvillous atrophy.

Gene ID: 1807