PANK3 antibody (AA 271-370) (HRP)

Catalog No. ABIN1416382

This Rabbit Polyclonal antibody specifically detects PANK3 in WB, ELISA, IHC (p) and IHC (fro). It exhibits reactivity toward Rat.

Quick Overview for PANK3 antibody (AA 271-370) (HRP) (ABIN1416382)

Target: PANK3 (Pantothenate Kinase 3 (PANK3))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PANK3 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-PANK3 Antibody (HRP)

Binding Specificity: AA 271-370

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Sheep,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PANK3

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for PANK3

Target: PANK3 (Pantothenate Kinase 3 (PANK3))

Alternative Name: PANK3

Background:

Synonyms: hPanK3, MGC16863, OTTHUMP00000160961, Pank3, PANK3_HUMAN, Pantothenate kinase 3, pantothenic acid kinase, Pantothenic acid kinase 3.

Background: The pantothenate kinase (PANK) family of proteins catalyzes the first step in coenzyme A (CoA) biosynthesis. Coenzyme A is an important coenzyme involved in the synthesis and oxidation of fatty acids, as well as the oxidation of pyruvate in the citric acid (Krebs) cycle. Pantothenate kinase 3 (PANK3) is a 370 amino acid member of the pantothenate kinase family that plays a role in the physiological regulation of the intracellular CoA concentration. Localized to the cytoplasm, PANK3 is regulated by feedback inhibition by CoA and its thioesters. PANK3 transfers a phosphate from ATP to pantothenate (Vitamin B5), resulting in formation of 4?-phosphopantothenate. Closely related to its family members, PANK1, PANK2 and PANK4, PANK3 is highly expressed in liver. Pantothenate kinase associated neurodegeneration (PKAN) results from mutations in the gene encoding PANK2, the only mitochondria targeted human PANK.

Gene ID: 79646

Pathways: Ribonucleoside Biosynthetic Process