FBXW2 antibody (AA 321-420) (Cy5)

Catalog No. ABIN1416696

This anti-FBXW2 antibody is a Rabbit Polyclonal antibody detecting FBXW2 in IF (cc) and IF (p). Suitable for Human.

Quick Overview for FBXW2 antibody (AA 321-420) (Cy5) (ABIN1416696)

Target: FBXW2 (F-Box and WD Repeat Domain Containing 2 (FBXW2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXW2 antibody is conjugated to Cy5

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-FBXW2 Antibody (Cy5)

Binding Specificity: AA 321-420

Predicted Reactivity: Human,Mouse,Rat,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FbxW2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for FBXW2

Target: FBXW2 (F-Box and WD Repeat Domain Containing 2 (FBXW2))

Alternative Name: FbxW2

Background:

Synonyms: F box and WD 40 domain containing protein 2, F box and WD repeat domain containing 2, F Box and WD40 Domain Protein 2, F box/WD repeat containing protein 2, FBW 2, FBW2, FBXW 2, Fwd2, Md6, Protein MD6.

Background: F box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F box proteins have been shown to be critical for the ubiquitin mediated degradation of cellular regulatory proteins. In fact, F box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F box proteins. A large family of mammalian F box proteins has recently been identified and classified into three groups based on the presence of either the WD 40 repeats, the leucine rich repeats, or the presence or absence of other protein protein interacting domains. The FBXW2 gene product, the second identified member of the F box gene family, contains multiple WD 40 repeats.

Gene ID: 26190