IGSF11 antibody (Cy3)

Catalog No. ABIN1419293

The Rabbit Polyclonal anti-IGSF11 antibody has been validated for WB and IF (p). It is suitable to detect IGSF11 in samples from Human, Mouse and Rat.

Quick Overview for IGSF11 antibody (Cy3) (ABIN1419293)

Target: IGSF11 (Immunoglobulin Superfamily, Member 11 (IGSF11))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IGSF11 antibody is conjugated to Cy3

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-IGSF11 Antibody (Cy3)

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human IGSF11

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for IGSF11

Target: IGSF11 (Immunoglobulin Superfamily, Member 11 (IGSF11))

Alternative Name: IGSF11

Background:

Synonyms: brain and testis specic immunoglobin superfamily protein, BTIGSF, CXADR like 1, CXADRL1, Igsf13, immunoglobulin superfamily member 11, Immunoglobulin superfamily member 11 precursor, MGC35227, V set and immunoglobulin domain containing 3, V set and immunoglobulin domain containing protein 3, VSIG3, IGS11_HUMAN.

Background: IGSF11 is also known as BTIGSF (brain and testis-specific immunoglobulin superfamily protein) or VSIG3 (V-set and immunoglobulin domain-containing protein 3) and is a 431 amino acid protein that is expressed as three isoforms. IGSF11 is highly expressed in testis and ovary and is also expressed in brain, kidney and skeletal muscle, localized to the cellular membrane as a single-pass membrane protein. IGSF11 is an immunoglobulin with V-type and C2-type domains that function in molecular recognition. When IGSF11 is in the trans position, it plays an important role in cell-cell adhesion via both homophilic and heterophilic interactions with other molecules. These cellcell interactions are also thought to be important for neuronal cell interactions, such as neuronneuron or neuronglia interactions, which are important for the development and function of the central nervous system. In addition, IGSF11 might also be involved interactions between Sertoli cells and spermatocytes, which are important associations during spermatogenesis. The IGSF11 gene is commonly upregulated in gastric cancer and IGSF11 is highly expressed in many types of human tumors, indicating that it may be useful as a target for immunotherapy.

Gene ID: 152404