UBE2V2 antibody (HRP)

Catalog No. ABIN1420240

This Rabbit Polyclonal antibody specifically detects UBE2V2 in WB, IHC (p). It exhibits reactivity toward Human, Mouse, Rat.

Quick Overview for UBE2V2 antibody (HRP) (ABIN1420240)

Target: UBE2V2 (Ubiquitin-Conjugating Enzyme E2 Variant 2 (UBE2V2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBE2V2 antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-UBE2V2 Antibody (HRP)

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MMS2/EDPF1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for UBE2V2

Target: UBE2V2 (Ubiquitin-Conjugating Enzyme E2 Variant 2 (UBE2V2))

Alternative Name: EDPF1

Background:

Synonyms: 1 alpha 25 dihydroxyvitamin D3 inducible, DDVit 1, DDVIT1, EDAF-1, EDAF1, EDPF-1, EDPF1, Enterocyte dferentiation associated factor EDAF 1, Enterocyte dferentiation promoting factor, Enterocyte dferentiation-associated factor 1, Enterocyte dferentiation-promoting factor 1, Methyl methanesulfonate sensitive 2, MMS 2, MMS2, MMS2 homolog, UB2V2_HUMAN, UBE2V 2, UBE2V2, Ubiquitin conjugating enzyme E2 variant 2, Ubiquitin conjugating enzyme E2v2, Ubiquitin-conjugating enzyme E2 variant 2, UEV 2, UEV2, Vitamin D3 inducible protein, Vitamin D3-inducible protein.

Background: Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.

Gene ID: 7336

Pathways: Positive Regulation of Response to DNA Damage Stimulus