TET2 antibody (AA 1165-1215) (Cy7)

Catalog No. ABIN1420646

The Rabbit Polyclonal anti-TET2 antibody has been validated for IF (p). It is suitable to detect TET2 in samples from Human, Mouse and Rat.

Quick Overview for TET2 antibody (AA 1165-1215) (Cy7) (ABIN1420646)

Target: TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TET2 antibody is conjugated to Cy7

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-TET2 Antibody (Cy7)

Binding Specificity: AA 1165-1215

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TET2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P): (1:50-200)
Optimal working dilution should be determined by the investigator.

Comment:

Exitation/Emission: 743nm/767nm

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at 4 °C for 12 months.

Expiry Date: 12 months

Target Details for TET2

Target: TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))

Alternative Name: TET2

Background: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.
Synonyms: MDS, KIAA1546, Methylcytosine dioxygenase TET2, TET2, Nbla00191

Gene ID: 54790

UniProt: Q6N021

Pathways: Warburg Effect