PROS1 antibody (AA 245-295) (Cy3)

Catalog No. ABIN1421021

The Rabbit Polyclonal anti-PROS1 antibody has been validated for WB and IF (p). It is suitable to detect PROS1 in samples from Human, Rat and Mouse.

Quick Overview for PROS1 antibody (AA 245-295) (Cy3) (ABIN1421021)

Target: PROS1 (PROS) (Protein S (PROS))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PROS1 antibody is conjugated to Cy3

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-PROS1 Antibody (Cy3)

Binding Specificity: AA 245-295

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Protein S/PROS

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for PROS1

Target: PROS1 (PROS) (Protein S (PROS))

Alternative Name: Protein S

Background:

Synonyms: Preproprotein S, Propiece of latent protein S, PROS 1, PROS, PROS_HUMAN, PROS1, Protein S alpha, Protein Sa, PS 21, PS 22, PS 23, PS 24, PS 25, PS 26, PS21, PS22, PS23, PS24, PS25, PS26, PSA, Vitamin K dependent protein S, Vitamin K-dependent protein S.

Background: Protein S (PROS) is a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated protein C (APC) and facilitates clearance of early apoptotic cells. In the plasma, circulating Protein S becomes inactive upon complexing with C4b-binding protein (C4BP), 60-70 % of Protein S circulates in complex with C4BP. Calcium-dependent association of C4BP-Protein S with apoptotic cells influences the regulation of complement activation. Protein S has APC-independent anticoagulant activity through direct inhibition of prothrombin activation via interactions with Factor X A, Factor V A and phospholipids. Autosomal dominant Protein S deficiency (levels 15 to 37 % of normal) correlates with severe recurrent venous thrombosis.

Gene ID: 5627

UniProt: P07225