ORAI2 antibody (HRP)

Catalog No. ABIN1421188

This Rabbit Polyclonal antibody specifically detects ORAI2 in WB and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for ORAI2 antibody (HRP) (ABIN1421188)

Target: ORAI2 (ORAI Calcium Release-Activated Calcium Modulator 2 (ORAI2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ORAI2 antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-ORAI2 Antibody (HRP)

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Orai2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for ORAI2

Target: ORAI2 (ORAI Calcium Release-Activated Calcium Modulator 2 (ORAI2))

Alternative Name: Orai2

Background:

Synonyms: C7orf19, CAP binding protein complex interacting protein 2, CBCIP 2, CBCIP2, Chromosome 7 open reading frame 19, FLJ12474, FLJ14733, FLJ44818, H_NH0514P08.8, Orai 2, ORAI calcium release activated calcium modulator 2, Protein orai 2, TMEM 142B, TMEM142B, Transmembrane protein 142B.

Background: Orai2 is a 254 amino acid multi-pass membrane protein that belongs to the orai family of proteins. Localizing to the plasma membrane, Orai2 plays an important role in store-operated calcium (SOC) entry, a process involving Ca2+ influx and replenishment of Ca2+ stores formerly emptied through the action of inositol 1,4,5-trisphosphate production and other Ca2+ mobilizing agents. CRAC channels are responsible for medi-ating calcium influx in T-cells and play an important role in the immune response. Orai2 specifically increases the Ca2+-selective current through coaction with the Ca2+ sensor Stim1.

Gene ID: 80228