ARL6IP5 antibody (Cy5)

Catalog No. ABIN1422072

The Cy5-conjugated Rabbit Polyclonal anti-ARL6IP5 antibody (ABIN1422072) specifically detects ARL6IP5 in WB and IF (p). The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for ARL6IP5 antibody (Cy5) (ABIN1422072)

Target: ARL6IP5 (Arl6ip5) (ADP-Ribosylation-Like Factor 6 Interacting Protein 5 (Arl6ip5))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARL6IP5 antibody is conjugated to Cy5

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-ARL6IP5 Antibody (Cy5)

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human JWA

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for ARL6IP5

Target: ARL6IP5 (Arl6ip5) (ADP-Ribosylation-Like Factor 6 Interacting Protein 5 (Arl6ip5))

Alternative Name: JWA

Background:

Synonyms: Addicsin, ADP ribosylation like factor 6 interacting protein 5, Aip 5, Aip5, ARL 6 interacting protein 5, ARL6IP5 antibody Cytoskeleton related vitamin A responsive protein, Dermal papilla derived protein 11, DERP 11, DERP11, Glutamate transporter EEAC 1 associated protein, Glutamate transporter EEAC1 associated protein, GTRAP3 18, Hp 22, Hp22, HSPC 127, HSPC127, JM 5, JM5, JMX, PRA 1 domain family 3, PRA 2, PRA1 domain family 3, PRA2, PRAF 3, PRAF3, Prenylated Rab acceptor protein 2, Protein JWa, Putative MAPK activating protein PM27, PRAF3_HUMAN.

Background: JWA is a four-transmembrane environmental responsive protein which binds to the CC chemokine recepor 5 (CCR5), a major co-receptor for human immunodeficiency virus (HIV). JWA is involved in environmental stress-responsive pathways in K562 cells, an erythroleukemia cell line derived from patients with chronic myeloid leukemia. Environmental stressors to K562 cells such as heat shock, a higher temperature than the ideal body temperature of the organism from which the cell line was derived, and oxidative stress, the production of oxygen-centered free radicals, regulate and increase the expres-sion of JWA. This response to environmental stressors suggests similiarity of JWA to heat shock protein 70 (HSP70), which is upregulated by heat stress and toxic chemicals.

Gene ID: 10550

Pathways: Dicarboxylic Acid Transport